{"id":2240,"date":"2013-11-01T12:01:00","date_gmt":"2013-11-01T11:01:00","guid":{"rendered":"https:\/\/der-arzneimittelbrief.com\/artikel\/2013\/wirken-clopidogrel-prasugrel-und-ticagrelor-staerker-bei-rauchern"},"modified":"2022-03-17T14:12:47","modified_gmt":"2022-03-17T13:12:47","slug":"wirken-clopidogrel-prasugrel-und-ticagrelor-staerker-bei-rauchern","status":"publish","type":"post","link":"https:\/\/der-arzneimittelbrief.com\/artikel\/2013\/wirken-clopidogrel-prasugrel-und-ticagrelor-staerker-bei-rauchern","title":{"rendered":"Wirken Clopidogrel, Prasugrel und Ticagrelor st\u00e4rker bei Rauchern?"},"content":{"rendered":"<p>Die Thrombozytenaggregationshemmer (TAH) Clopidogrel und Prasugrel sind Prodrugs, aus denen \u00fcber verschiedenen Zytochrom &#8211; ganz wesentlich \u00fcber CYP1A2, CYP3A4 und CYP2C19 &#8211; die aktiven Metabolite gebildet werden. Protonenpumpen-Hemmer verringern die Aktivit\u00e4t von CYP2C19 und damit die Umwandlung und Wirkung von Clopidogrel. Die Konsequenzen haben wir eingehend diskutiert (1). Andere Substanzen stimulieren Cyp1A2, z.B. Theophyllin, Olanzapin, [&hellip;]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Die Thrombozytenaggregationshemmer (TAH) Clopidogrel und Prasugrel sind Prodrugs, aus denen \u00fcber verschiedenen Zytochrom &#8211; ganz wesentlich \u00fcber CYP1A2, CYP3A4 und CYP2C19 &#8211; die aktiven Metabolite gebildet werden. Protonenpumpen-Hemmer verringern die Aktivit\u00e4t von CYP2C19 und damit die Umwandlung und Wirkung von Clopidogrel. Die Konsequenzen haben wir eingehend diskutiert (1). Andere Substanzen stimulieren Cyp1A2, z.B. Theophyllin, Olanzapin, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[684,495,1272,1590,1596,2631,73,4485,731,4484,71,85,86,498,65,87,4353,1033,79,784,2117,727,2005,3163,1031,783],"class_list":["post-2240","post","type-post","status-publish","format-standard","hentry","category-allgemein","tag-akutes-koronarsyndrom","tag-angina-pectoris","tag-arteriosklerose","tag-caprie-studie","tag-charisma-studie","tag-clarity-studie","tag-clopidogrel","tag-credo-studie","tag-cure-studie","tag-current-oasis-7-studie","tag-herzinfarkt","tag-koronarangiografie","tag-koronarangiographie","tag-koronare-herzkrankheit","tag-myokardinfarkt","tag-perkutane-transluminale-koronare-angioplastie","tag-plato-studie","tag-prasugrel","tag-ptca","tag-rauchen","tag-tabak","tag-thrombozytenaggregationshemmer","tag-ticagrelor","tag-trilogy-acs-studie","tag-triton-timi-38-studie","tag-zigarettenrauchen"],"_links":{"self":[{"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/posts\/2240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/comments?post=2240"}],"version-history":[{"count":0,"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/posts\/2240\/revisions"}],"wp:attachment":[{"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/media?parent=2240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/categories?post=2240"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/der-arzneimittelbrief.com\/api\/wp\/v2\/tags?post=2240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}